Scientists partially restored the work of the heart and brain of a pig an hour after its death

Scientists partially restored the work of the heart and brain of a pig an hour after its death

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Scientists from the Yale School of Medicine, using the OrganEx technology they developed, restored blood circulation and cellular activity of vital internal organs of pigs, such as the heart and brain, after hour after animal death. The work of biologists published in the journal Nature, the editors of which also briefly retold scientists article.

During the experiment, the researchers connected pigs that had artificially induced cardiac arrest to the perfusion system, which pumped through the blood vessels of the animals a special solution containing, first of all, the blood of animals, as well as a special composition of 13 compounds designed to restore cellular vitality. . In particular, the composition of the solution included anticoagulants – substances that block blood clotting, and an oxygen carrier, “artificial” Hemopure hemoglobin.

As a result of pumping the solution, oxygen began to flow to the tissues of the animals, after which some of the functions of their organs, such as the contraction of the heart and the activity of the liver and kidneys, quickly recovered. AT control groups That did not happen. Only in the experimental group, animal tissues were not damaged by prolonged oxygen starvation.

The new technology made it possible to preserve the integrity of some brain tissues, but at the same time, the authors of the work did not see any coordinated brain activity, indicating the restoration of brain activity. In addition, the heart was not completely restarted.

The authors of the study emphasize that, given the lack of normal electrical activity of the brain, in this case we are not talking about resuscitation of a pig after death – but only about preserving the vital activity of tissues. “We made the cells do things that they were not capable of when the animals were dead,” said one of the authors of the work, neuroscientist Zvonimir Wrselja.

Scientists noted that dead pigs, which were connected to the OrganEx system, began to involuntarily twitch their head, neck and torso after the contrast dye was injected into the brain. The researchers were unable to explain this phenomenon, considering it unlikely that the impulses originated in the brain. They assumed that the impulses originated in the spinal cord, which can control some motor functions independently of the brain.

The authors of the work expect that in the future their technology will be used to save organs for transplantation.

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Source: meduza.io

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