By comparing the neutralization activity of antibodies triggered by Pfizer and Johnson & Johnson’s Covid vaccines, a research team from New York University has determined that the latter may be ineffective against the Delta variant of the SARS-CoV coronavirus. -2. Scientists begin recommending a booster for the single-dose vaccine.

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The single-dose vaccine of Johnson & Johnson it may be ineffective against the Delta variant of coronavirus SARS-CoV-2, the strain which is driving the third / fourth wave of infections mainly due to greater transmissibility, 50 percent higher than that of Alpha variant (ex English B.1.1.7) at the base of last winter’s peaks. In light of this potential risk of infections “revolutionary”, That is, affecting people immunizzate, many researchers are recommending to submit to a recall anyone who received the single dose of Johnson & Johnson’s vaccine. Preferably, explain the authors of the new study, it would be better to administer a vaccine as a second dose Messenger RNA, or the BNT162b2/Tozinameran of Pfizer-BioNTech ol’mRNA-1273/CX-024414 of Modern NIAID. As emerged from some studies, in fact, the heterologous vaccination between a dose of AstraZeneca (a adenoviral vector such as J&J) and a vaccine a mRNA induce una immune response even more robust.

It was an American research team led by scientists from the Department of Microbiology of the Grossman School of Medicine at New York University who collaborated to determine that Johnson & Johnson’s vaccine may not be very protective against the Delta variant. close contact with colleagues from the Department of Medicine and the Langone Vaccine Center. The researchers, coordinated by Professor Nathaniel R. Landau, came to their conclusions after comparing the neutralizing antibody titers triggered by the Pfizer vaccine and those of the J&J vaccine, verifying their neutralization activity against different variants of SARS-CoV-2 (Beta, Delta, Delta Plus e Lambda). While in the first case they showed a modest resistance to neutralization, “the antibodies elicited byAd26.COV2.S (the J&J vaccine ed) from a significant fraction of vaccinated individuals they were of low neutralizing titer (IC50 <50), ”the study authors wrote. "The data underscore the importance of surveillance of the breakthrough infections that cause severe cases of COVID-19 and suggest the benefit of a second immunization after Ad26.COV2.S to increase protection against variants," said Professor Landau and colleagues. .

It should be borne in mind that of the four approved Covid vaccines for emergency use by the European Medicines Agency (EMA) and the Italian Medicines Agency (AIFA), only one is based on a single dose, Johnson & Johnson’s Ad26.COV2.S or JNJ-78436735, developed by scientists at Janssen Pharmaceutica and Beth Israel Deaconess Medical Center (BIDMC). Based on the findings of the Delta variant investigations conducted in the United Kingdom, where it is dominant since mid-May, the single dose of AstraZeneca or Pfizer barely protects about 30 percent against it, while the efficacy rises significantly with the two doses, reaching almost 100 percent against it.hospitalization and the death. Since J&J’s vaccine is based on the same technology as AstraZeneca and the effectiveness of one dose of the latter is considered low, several experts are recommending the booster. “The message we wanted to give was not that people shouldn’t get the J&J vaccine, but we hope it will be boosted with another dose of J. & J in the future. or a recall with Pfizer or Moderna, ”Professor Landau told the New York Times. Professor John Moore, virologist at Weill Cornell Medicine in New York also shares the same opinion: “I have always thought, and I have often said, that the vaccine of J. & J. it is a two-dose vaccine ”.

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The New York University “Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants” study, published in BioRXiv and not yet peer-reviewed, takes into accountneutralizing activity antibodies, which is only one of the components of ours immune system. For example, a fundamental “arm” is that relating to thecellular immunity based on T cell, which hunt for cells already infected with the virus and eliminate them. The data from the new study “does not speak to the full nature of immune protection,” Johnson & Johnson spokeswoman Professor Seema Kumar told the NYT. In other studies, explains the scientist, the vaccine “generated strong and persistent activity against the rapidly spreading Delta variant.” For example, a recent survey found that the neutralizing activity of antibodies triggered by the J&J vaccine would be high even 8 months away dose inoculation, a result in stark contrast to that of the new research. At the moment, the international health authorities do not believe that a recall is necessary for those who have received the single-dose vaccine from Johnson & Johnson, but in the United States several scientists have already voluntarily undergone this procedure and are clamoring for the “boost” to be given to all 13 million Americans vaccinated with this drug.

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