Tens of millions of people in the US may not have responded well to the COVID-19 vaccine

People undergoing chemotherapy or immunosuppressants, transplant patients, individuals with primary immunodeficiencies … There are several groups with pathologies that, after a year and a half of living with COVID-19 and after almost six months of application of the vaccine, they remain in doubt as to whether the serum actually protects them against disease.

This is the case for people who are immunosuppressed for one reason or another, like June Tatelman, a 73-year-old American, who saw her hopes of returning to normal after the vaccine falter when her doctor gave her the bad news. While walking through Boston with her dog, this elderly woman with a problem of inflammation in the blood vessels of the lungs met her doctor, who told her that maybe it wasn’t protected, as he has told the CNN.

The doctor informed her that some medical studies suggested that the vaccine might not work properly in people who were taking medications like his, so he recommended that a test be carried out to verify it. In doing so, he found that he had no antibodies.

Current evidence shows that immunosuppressed people may not generate optimal protection through vaccines and, therefore, a group of researchers from the universities of Glasgow, Birmingham, Oxford, Liverpool, Imperial College and Leeds Teaching Hospitals analyze the impact of these serums in patients with these conditions. This is the OCTAVE trial, with funding from the Medical Research Council (MRC).

In this sense, experts point to immunosuppressed people and the elderly such as those immunized who are more likely to present a clinical picture caused by the coronavirus after completing the vaccination regimen, because they may present a less potent response to the compound against COVID and develop a slightly more severe form of the disease.

Therefore, specialists call continue to respect protection measures and to observe the evolution of these patients after receiving the punctures, because it can also happen that the reaction of their immune system is good and they are practically at the same level as any other immunized with these drugs.

File - Rapid test of COVID-19 antigens carried out in Palma.

However, the fact that they are more likely to become infected and develop symptoms once the preparation against COVID-19 has been administered does not necessarily mean that they will develop a serious form of the disease or that the vaccine did not work.

Likewise, the fact of not having detected antibodies in a test after the vaccine does not mean that the patient is not protected. The explanation may be that the test used is not correct.

In fact, when you choose to perform a rapid antibody test on a person who has received the vaccine, it is often negative. What happens is not that the preparation does not induce the production of antibodies, but that these are of a type that the method is unable to detect.


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