Doing an antibody test before and after the vaccine does not mean having a measure of vaccination-induced immunity. Although the examination returns the antibody value directed against the coronavirus, the protection from the disease it is not due to antibodies alone but to the cooperation of different types of immune responses, including cellular ones. The test therefore has an important role in identifying people who may have had Sars-Cov-2 infection but it makes little sense in assessing the level of immunity, as protection is not linked to the antibody titre alone.

In other words, the concentration of antibodies in the blood it does not directly reflect immunity, as indicated by a series of studies that evaluated the role of specific immune cells (T lymphocytes) in contributing to protection against the virus. “Antibodies alone can protect even at relatively low levels, but T lymphocytes are also needed if the antibody levels are insufficient“Indicated the researchers of the Center for Virology and Vaccine Research at Harvard Medical School in Boston who, in an article published in Nature, clarified the different importance of antibodies and T cells in the protection against Covid-19.

According to the European Center for Disease Prevention and Control (ECDC), the European Union agency for disease prevention and control “Although some antibody tests show evidence of an immune response, it is not known whether the level of antibodies offers sufficient protection and how long this protection lasts.“. Food and Drug Administratin (FDA) has also recommended do not use antibody tests to assess immunity. “The FDA – indicates the US Medicines Agency in a notice – remember the limitations of serological tests in people who have received the vaccination. They can play an important role in identifying people who have been infected with Sars-Cov-2, however the test should not be used to measure immunity or protection against Covid-19. especially after receiving the vaccine”.

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