Do you want to lose kilos? Looking to stay at your ideal weight? The key may be to control a protein in your stomach. called gastroquina-1 or GKN1, according to a study recently published in ‘Scientific Reports’, in which it is concluded that inhibition of GKN1 may be a means of preventing obesity.

Gastroquin-1 is an anti-amyloid protein that is abundantly and specifically secreted in the stomach lumen, so the work consisted of examining whether GKN1 played a role in the development of this pathology and the regulation of the gut microbiome.

“These findings identify an additional new mechanism for the regulation of diet-induced obesity by the stomach.”

Overweight and obesity are defined, according to the World Health Organization (WHO), as a abnormal or excessive accumulation of fat which can be harmful to health. Since 1975, obesity has nearly tripled worldwide. In 2016, more than 1.9 billion adults aged 18 and over were overweight, of which more than 650 million were obese. In 2016, 39% of adults aged 18 and over were overweight, and 13% were obese.

The body mass index (BMI) is a simple indicator of the relationship between weight and height which is frequently used to identify overweight and obesity in adults. It is calculated by dividing a person’s weight in kilos by the square of their height in meters (kg / m2).

Main conclusions

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“The main conclusion and the most remarkable finding of this study is that the absence of GKN1, a stomach-specific and secreted anti-amyloidogenic protein, protects from diet-induced obesity. Specifically, GKN1 is required for the full development of excess body fat that occurs in mice with age on a normal food diet, or after consuming a high-fat diet. Since GKN1 is produced exclusively in the stomach, these findings identify an additional new mechanism for the regulation of diet-induced obesity by the stomach, ”the researchers note.

The research team for this new scientific finding made in mice is made up of Anne-Marie C. Overstreet, Bernadette E. Grayson, Antonia Boger, Danika Bakke, Erin M. Carmody, Cayla E. Bales, Shirley C. Paski, Stephen F Murphy, Christopher R. Dethlefs, Kara J. Shannon, Katie R. Adlaka, Claire E. Wolford, Vincent J. Campiti, Christina V. Raghunandan, Randy J. Seeley, and David L. Boone.

Most of the population lives in countries where overweight and obesity claim more lives than underweight

“Obesity can be prevented and this new discovery could contribute to the development of therapies that would help people who are struggling to lose weight and maintain themselves, “says the doctor. Alfredo Alonso Pose, Head of Service at the Hospital Universitario del Sureste de Madrid and member of the Obesity Unit at Hospital Ruber Juan Bravo.

The doctor details us that “the tubular gastrectomy or gastric sleeve in which part of the stomach is removed turning it into a tube causes a reduction in the production of ghrelin, which is another gastric orexigenic hormone (which does not make you eat), in addition to also reducing GKN1, which explains the good results that are being obtained with this surgical technique ”.

Overweight and obesity in data

  • Most of the world’s population lives in countries where being overweight and obese take more people’s lives than underweight.
  • According to the WHO, in 2016, more than 1.9 billion adults aged 18 and over were overweight, of which, more than 650 million were obese.
  • This year, 41 million children under the age of five were overweight or they were obese.
  • And there was more than 340 million children and adolescents (5 to 19 years old) who are overweight or obese.
  • The 39% of adults aged 18 and over (39% of men and 40% of women) were overweight.
  • In general, in 2016 about 13% of the world’s adult population (11% of men and 15% of women) were obese.
  • Between 1975 and 2016, the global prevalence of obesity it has almost tripled.
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